Thank you for this great question! Prior studies show that children who are biologically susceptible to environmental influences, in accordance with the biological sensitivity to context theory, may also be more responsive to treatment. For example, one study found that children with higher heart rate experienced significant reduction in problem behaviors following intervention, compared to those with lower heart rate who did not benefit from the intervention (Stadler et al., 2008). Additional research examining biological and social factors that may influence intervention efficacy is needed.

Stadler, C., Grasmann, D., Fegert, J. M., Holtmann, M., Poustka, F., & Schmeck, K. (2008). Heart rate and treatment effect in children with disruptive behavior disorders. Child Psychiatry and Human Development, 39(3), 299–309.